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"Toronto Lake is a lake in Sullivan County, New York. It is located in the town of Bethel. References * Category:Lakes of New York (state) Category:Lakes of Sullivan County, New York "
"Ordnance Survey map from 1860 showing the Fforestfach area Foresthall House (or Fforestfach House) was a mansion-like house that existeded in the Swansea suburb of Fforestfach until the 1970s, when the old and crumbling mansion was bought by Swansea Council and demolished in order to make way for various new estates. The mansion was located on the western side of Ravenhill, and had a garden stretching from the mansion itself to the far back end of Cadle Woods. The mansion can be dated from the many Ordnance Survey maps from 1861–8 that show it. The owner of the mansion planted many trees around his land, most notably the Horse Chestnut Tree, which can still be seen today. The owner of the house is blamed for the Japanese knotweed problem in the Swansea area, as in 19th-century Japanese knotweed was used commonly as a potted plant for ornamental use, and was also used on his land to prevent soil erosion. Category:Buildings and structures in Swansea Category:History of Swansea "
"Oncophage (brand name Vitespen), also known as cancer vaccine heat shock protein peptide complex-96 and cancer vaccine HSPPC-96, is a personalized cancer vaccine developed by the American biopharmaceutical company Antigenics Inc. (now Agenus) that is evaluated in multiple clinical trials. It has been granted fast track and orphan drug designations from the US Food and Drug Administration for kidney cancer, metastatic melanoma, and glioma. The investigational agent is not yet approved in the US but was approved in Russia in April 2008 for patients who have earlier-stage kidney cancer. The European Medicines Agency is evaluating conditional approval for Oncophage. Oncophage is one of a group of new drugs called cancer vaccines that intend to train the body's immune system to fight the cancer. While chemotherapy is often accompanied by severe side effects, cancer vaccines tend to have only minimal ones (often only inflammations of the injection site). In April 2009, the World Vaccine Congress named Oncophage as the best therapeutic vaccine.http://www.terrapinn.com/2009/wvcwawards/ However, after a negative opinion from the Committee for Medicinal Products for Human Use (CHMP) on 19 November 2009, Antigenics Inc. decided to withdraw their application for approval by the European Medicines Agency shortly after on 23 November 2009. Description Oncophage (Vitespen) is a vaccine made from a patient's tumor by extracting heat shock protein gp96 and its associated peptides.http://www.antigenics.com/products/cancer/oncophage/ Clinical trials One trial is evaluating the investigational agent alone in patients with first recurrence of glioma while the second trial is evaluating Oncophage (Vitespen) in combination with Temozolomide, a common chemotherapy, in patients that are newly diagnosed with brain cancer. A first phase I clinical trial in glioma extended median survival of the group of patients, which was diagnosed with multiple recurrencies of glioma, to over 10 months. References External links *New website (the company changed its name and the name of the vaccine *Information on the manufacturer website Category:Cancer vaccines Category:Orphan drugs Category:Experimental cancer treatments "